Can Herpes Cause Alzheimer’s? Exploring the Surprising Link Between HSV-1 and Brain Health

  • "Can Herpes Cause Alzheimer’s? Exploring the Surprising Link Between HSV-1 and Brain Health"
  • HSV-1
  • HSV-1 and Alzheimer’s: An Unlikely Link Emerges
  • Scientists revealed in a recent BMJ Open article that there is a possible link between HSV-1 and Alzheimer’s disease, meaning viral infections might increase the risk of cognitive decline.
  • HSV-1: Quiet, Yet Active
  • HSV-1, which is the cause of cold sores, is a virus that gravitates toward nerves. Nearly two-thirds of the world’s younger population has this virus, says the World Health Organization, most of them without knowing it.
  • After you get HSV-1, it will usually not cause more problems, lying quietly and dormant in the nerves. Sometimes, stress or illness allows the virus to activate and produce symptoms called cold sores, even though in most cases the virus stays silent.
  • The Study: What the Data Reveals
  • Data from nearly 340,000 Alzheimer’s patients were examined, and 0.44% had previously contracted HSV-1. Meanwhile, almost half that number, 0.24%, was found to have HSV-1 antibodies in those individuals who had not been given an Alzheimer’s diagnosis. Accordingly, people who test positive for HSV-1 are 80% more likely to get Alzheimer’s. But if antivirals were used, the chances of developing Alzheimer’s decreased by up to 17% for patients.
  • But How Are They Connected?
  • While the study cannot prove that HSV-1 causes Alzheimer’s, it does find a strong relationship between the two. Herron and her team suggest that HSV-1 could increase inflammation in the brain and result in more amyloid-beta plaques, which are known to appear in Alzheimer’s sufferers. That said, how autism is biologically affected is still unknown.
  • Important Caveats
  • There are some constraints on the research. It’s likely that since insurance claims were used as data, cases of HSV-1 that were not noticed by doctors were not reported. Moreover, HSV-1 was less common in the study than around the world, which might limit the applicability of the results.
  • Conclusion: A New Perspective and the Need for Further Research
  • Even though the study does not prove a cause-and-effect link, it prompts us to ask if viral infections such as HSV-1 might have an effect on our brain.
  • As a direct link is yet to be confirmed, the results reveal a new area for investigation and stress the role viruses could play in these diseases.

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